VICTOR TSANG
Chief, Immunology Branch, Division of Parasitic Diseases, CDC
Ph.D., 1976
University of Georgia
RESEARCH
The goals of my program are to improve diagnosis and to develop and evaluate better control strategies, including vaccines, for parasitic diseases. Current projects in my laboratory include characterization of immunological changes in host (human and non-human primates) isotypes resulting from successful treatment of schistosomiasis; development of quantitative antigen assays for schistosomiasis and application of such assays under field (Eqypt and Peoples Republic of China) conditions; development of automated and field-applicable diagnostic assays for cysticercosis and their field application in Peru; integration of advanced diagnostic technologies in the systematic control of cysticercosis; quantitative assay development for Cryptosporidium parvum oocysts and sporozoite in water and fecal samples; characterization of the basic mechanism and optimal configuration for immunoaffinity systems; immunochemical and biophysical characterization of solid-phase immune reactions, with special emphasis on the quantitative efficacy of immunoassays (enzyme- and chemiluminescence-based systems); production of recombinant DNA/monoclonal derived gene products of diagnostic antigens from parasite species.
| CONTACT INFORMATION |
| (770) 488-4056, vct1@cdc.gov |
SUPPORT STAFF
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| Scheel |
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POSITION | |
E-MAIL |
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| Christina Scheel | |
Grad Student | |
cscheel@arches.uga.edu |
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REPRESENTATIVE PUBLICATIONS
Tsang, V.C.W., J.A. Brand, A.E. and Boyer. 1989. "An enzyme-linked immunoelectrotransfer blot assay and glycoprotein antigens for diagnosing human cysticercosis Taenia solium." J. Inf. Dis. 159:50-59.Tsang, V.C.W., A.E. Boyer, J.B. Pilcher, M.L. Eberhard, C.B. Reimer, G. Zea-Flores, R. Zea-Flores, W. Zhou, and F.O. Richards. 1991. "Gatemalan human onchcerciasis: I. Systematic analysis of patient populations, nodular antigens and specific isotypic reactions." J. Immunol. 146:3993-4000.
Boyer, A.E., V.C.W. Tsang, M.L. Eberhard, G. Zea-Flores, A. Hightower, J.B. Pilcher, R. Zea-Flores, W. Zhou, C.B. Reimer. 1991. "Gatemalan human onchcerciasis: II. Evidence for IgG3 involvement in acquired immunity to Onchocerca volvulus and identification of possible immune-associated antigens." J. Immunol. 146:4001-4010.
Tsang, V.C.W., and P.P. Wilkins. 1991. "Optimum dissociating condition for immunoaffinity and preferential isolation of antibodies with high specific activity." J. Immunol. Methods 138:291-299.
Wilkins, P.P., S.B. Slemenda, S.E. Maddison, and V.C.W. Tsang. 1991. "Isotypic analysis of humoral responses in rhesus monkeys to an adult microsomal antigens of Schistosoma mansoni: an indicator of successful treatment." Am. J. Trop. Med. Hyg. 45:629-635.
Garcia, H.H., Martinez, R. Gilman, G. Herrera, V.C.W. Tsang, J.B. Pilcher, M. Diaz, M. Verastegui, C. Gallo, M. Porras, M. Alvarado, Narranjo, E. Miranda. 1991. "Cysticercosis in endemic zones: a frequently misdiagnosed condition." The Lancet 338:549-551.
Garcia, H.H., R. Gilman, M. Martinez, V.C.W. Tsang, J.B. Pilcher, F. Diaz, M. Porras, M. Alvarado, E. Orrillo, P. Torres, E. Miranda. 1993. "Cysticercosis as a major cause of epilepsy in Peru." The Lancet 341:197-200.
Tsang, V.C.W., and M. Wilson. 1995. "Taenia solium cysticercosis is an under-recognized but serious public health problem." Parasitol. Today 11:124-126.
Garcia, H.H., R.H. Gilman, M.A. Tovar, E. Flores, R. Jo, V.C.W. Tsang, F. Diaz, P. Torres, E. Miranda, and the CWG. 1995. "Factors associated with Taeniz solium cysticercosis: analysis of 946 Peruvian neurologic patients." J. Am. Top. Med. Hyg. 52:145-148.
Cetron, M.S., L. Chitsulo, J.J. Sullivan, J. Pilcher, M. Wilson, J. Noh, V.C.W. Tsang, A.W. Hightower, D.G. Addis. 1996. "Schistosomiasis and Lake Malawi: transmission and risk to expatriates and tourist." Lancet 348:1274-1278.
Evans, C.A.W., A.E. Gonzales, R.H. Gilman, M. Verastegui, H.H. Garcia, A. Chavera, J.B. Pilcher, V.C.W. Tsang, and The CWG*. 1997. "Immunotherapy for porcine cysticercosis: implications for prevention of human disease." Am. J. Trop. Med. Hyg. 56:33-37.
Wilkins, P.P., J.C. Allan, M. Verastegui, M. Acosta, A.G. Eason, H.H. Garcia, A.H. Gonzalez, R.H. Gilman, V.C.W. Tsang. "Development of a serologic assay to detect taenia solium taeniasis." Am. J. Trop. Med. Hyg. In press.