MRI:

Human and large animal imaging: A state-of-the-art, General Electric 16-channel fixed-site Signa HDx 3.0 Tesla Magnetic Resonance Imaging (MRI) magnet is the anchor technology within the BIRC. The magnet makes available multiple magnetic resonance imaging techniques including magnetic resonance imaging for structural tissue imaging (MRI), functional neuroimaging (fMRI) for studies of brain activation in real time, magnetic resonance spectroscopy (MRS) for the study of chemical changes in the brain, and magnetic resonance angiography (MRA) for the study of vascular changes throughout the system. Multinuclear spectroscopy (MNS) has recently been added for enhanced spectroscopic studies and includes phosphorous-31.

Small animal imaging: A new, Varian Magnex 7 Tesla, 210 mm horizontal bore, actively shielded MRI system will be installed in the BIRC approximately February, 2010. The magnet will allow MRI and MRS tissue imaging at a high level of resolution and will be available to the research community. The new magnet allows cutting edge monitoring of the development and treatment of disease in small animal models (rats and mice) and provides non-invasive monitoring of both anatomical and metabolic changes without the statistical aberrations introduced by post-sacrifice analysis.

MEG: A CTF Omega Whole-cortex magnetoencephalography system with 143 channel MEG and 32 channel EEG, all enclosed in a state-of-the-art magnetically shielded room is available for researchers. Additionally, an EGI Geodesic System 200 Electroencephalography system with 256-channel head capabilities is maintained in the BIRC. Magnetic encephalography (MEG) is a new and exciting technology allowing high temporal resolution of brain function that complements MRI structural scanning.

EEG: An EGI Geodesic System 200 Electroencephalography system with 256-channel head capabilities is maintained in the BIRC. Dense-Array Electroencephalography (EEG) is another high temporal resolution technology that combined with MEG, can identify specific areas of the brain responsible for various brain functions.

Simulator: A fully functional MRI simulator is housed within the BIRC. The simulator is a life-size “mock-up” of the MR magnet, complete with stimulus presentation and behavioral data acquisition computing equipment. The simulator is used to develop new protocols, train research participants, and acclimate participants to the MR environment.

Software: A variety of software tools are available for all investigators via a multi-computer workstation environment on the premises, supporting Linux and Windows versions of most programs. Image processing software includes BESA, CURRY, SPM, FSL, AFNI, MATLAB, E-Prime, Presentations, and Brain Wave.