Jason Langley
Current research interests: My primary interest is contrast enhanced magnetic resonance imaging. Specifically I am interested in developing positive contrast methods to aid in the detection of iron oxide-based contrast agents, developing quantification procedures for iron oxide-based contrast agents, and developing quantification procedures for gadolinium-based contrast agents. I am interested in using the gadolinium-based contrast agent quantification procedures to estimate the arterial input function in dynamic contrast enhanced magnetic resonance imaging. Current methods of estimating the arterial input function involve measuring the concentration of the contrast agent in the blood at different points in time. This procedure is invasive and time consuming. An accurate and noninvasive method of estimating the arterial input function will improve pharmacokinetic modeling. Secondary interests include estimating the physiological noise levels in the brain, correction of susceptibility-induced distortions in echo planar imaging, and phase unwrapping. Peer-Reviewed Publications: Langley, J. and Zhao, Q. Unwrapping MR phase maps with Chebyshev polynomials, Magnetic Resonance Imaging, Published online 30 June 2009, DOI:10.1016/j.mmri.2009.05.013Zhao, Q., Langley, J., Faraco, C., and Miller, LS. Correction of susceptibility-induced distortion in diffusion tensor imaging with a moment-based phase unwrapping method. International Journal of Functional Informatics and Personalized Medicine, 2(2):136-149, 2009 Langley, J. and Zhao, Q. A model-based phase unwrapping algorithm using Gegenbauer polynomials. Physics in Medicine and Biology, In press McCully, K., Turner, T., Langley, J., and Zhao, Q. The reproducibility of measurements of intramuscular magnesium concentrations. Dynamic Medicine, Under Review Zhao, Q., Langley, J., Lee, S., and Liu, W. Generation of positive contrast from a phase image using phase gradient mapping. NMR in Biomedicine, Under Review Langley, J. and Zhao, Q. Quantification of SPIO nanoparticles using phase gradient mapping. NMR in Biomedicine, Under Review Langley, J., Brice, R., and Zhao, Q. A recursive approach to the moment-based phase unwrapping method. In preparation Abstracts / Conference Proceedings: Langley, J. and Zhao, Q. Unwrapping MR phase maps with Chebyshev moments, Proceedings of the 30th Annual International IEEE EMBS Conference, Vancouver, BC, August 20-24, 2008, p. 4043-4046Lee, S., Langley, J. and Zhao, Q. Phase gradient mapping (PGM) for positive contrast generation, Proceedings of the 17th Annual Meeting of the International Society of Magnetic Resonance in Medicine, Honolulu, Hawaii, US, April 18-24, 2009, p. 899 Langley J. and Zhao, Q. 3D phase unwrapping based on expansion in Chebyshev polynomials, Proceedings of the 17th Annual Meeting of the International Society of Magnetic Resonance in Medicine, Honolulu, Hawaii, US, April 18-24, 2009, p. 2914 Zhao, Q. and Langley, J. Probing the physiological activity on fMRI time series, Proceedings of the 15th Annual Meeting of the Organization for Human Brain Mapping, San Francisco, CA, US, June 18-23, 2009, Poster Number 390 Faraco, C., Smith, D., Langley, J., Zhao, Q., and Miller, S. Mapping the working memory network using the OSPAN task, Proceedings of the 15th Annual Meeting of the Organization for Human Brain Mapping, San Francisco, CA, US June 18-23, 2009, Poster Number 539 Langley, J. and Zhao, Q., Quantification of SPIO nanoparticles using phase gradient mapping. Accepted for presentation at the 31st Annual International IEEE EMBS Conference, Minneapolis, MN
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