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Mark Jensen

College of Public Health: Epidemiology and Biostatistics

Posted in: Epidemiology faculty

Last updated: Aug 22, 2007 - 10:13:31 AM

Assistant Professor of Epidemiology
maj@uga.edu

N123 Paul D. Coverdell Center
University of Georgia
Athens, GA 30602
706.542.2423 (voice)
706.583.0695 (fax)

Educational Background

Ph.D., 2000, University of Chicago

Research Interests

My interests lie in understanding the pathogenic, evolutionary, and epidemiological meaning of genetic changes in a variety of microorganisms and disease. My work involves interpreting biological sequence data gathered from pathogen populations within humans, with the help of mathematical models and computer simulations based on ideas from population genetics and epidemiology. I am particularly interested in the application of molecular epidemiology and population genetics to infections that disproportionately affect people in the developing world. My projects include work on several infectious agents including HIV, Vibrio cholerae and Streptococcus pneumoniae. I use techniques from biological sequence analysis (including phylogenetics and pattern recognition bioinformatics), molecular evolution simulation, biostatistics, and dynamical systems modeling, to address problems involving microbial evolution within individuals, microbial genetic factors that influence disease course, the influence of environmental microbial interactions on epidemics, and vaccine development. My empirical work focuses on the molecular epidemiology of HIV, and of bacterial population biology as it pertains to infectious disease.

Selected Publications

Jensen, M.A., M. Coetzer, A.B. van’t Wout, L. Morris, and J.I. Mullins. 2006. A reliable phenotype predictor for HIV-1 subtype C based on envelope V3 sequences. J. Virol. 80: 4698-4704.
Jensen, M.A., S.M. Faruque, J.J. Mekalanos, and B.R. Levin. 2006. The role of bacteriophage in the control of cholera epidemics. Proc. Natl. Acad. Sci. U.S.A. 103: 4652-4657.
Mullins, J.I. and M.A. Jensen. 2006. Evolutionary dynamics of HIV-1 and the control of AIDS. Curr. Top. Microbiol. Immunol. 299: 171-192.
Troyer, R.M., K.R. Collins, A. Abrahal, E. Fraundorf, D.M. Moore, R.W. Krizan, Z. Toossi, R.L. Colebunders, M.A. Jensen, J.I. Mullins, G. Vanham, and E.J. Arts. 2005. Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression. J. Virol. 79: 9006-9018.
Gottlieb, G.S., D.C. Nickle, M.A. Jensen, K. G. Wong, J. Grobler, F. Li, S.-L. Liu, C. Rademeyer, G.H. Learn, S.S.A. Karim, C. Williamson, L. Corey, J.B. Margolick, and J.I. Mullins. 2004. Dual HIV-1 infection associated with rapid disease progression. Lancet 363: 619-622.
Shriner, D., R. Shankarappa, M.A. Jensen, D.C. Nickle, J.E. Mittler, J.B. Margolick, and J.I. Mullins. 2004. Influence of random genetic drift on HIV-1 env evolution during chronic infection. Genetics 166: 1155-1164.
Liu, Y., D.C. Nickle, D. Shriner, M.A. Jensen, G.H. Learn, Jr., J.E. Mittler, and J.I. Mullins. 2004. Molecular clock-like evolution of human immunodeficiency virus type 1. Virology 329: 101-108.
Jensen, M.A., F.-S. Li, A.B. van’t Wout, D.C. Nickle, D. Shriner, H.-X. He, S. McLaughlin, R. Shankarappa, J.B. Margolick, and J.I. Mullins. 2003. Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of HIV-1 env V3 loop sequences. J. Virol. 77: 13376-13388.
Jensen, M.A. and A.B. van’t Wout. 2003. Predicting HIV-1 coreceptor usage using sequence analysis. AIDS Rev. 5: 104-112.
Nickle, D.C., M.A. Jensen, G.S. Gottlieb, D. Shriner, G.H. Learn, A.G. Rodrigo and J.I. Mullins. 2003. Consensus and ancestral state HIV vaccines. Science 299: 1515-1517.
Brumme, Z.L., W.W.Y. Dong, B. Yip, B. Wynhoven, N.G. Hoffman, R. Swanstrom, M.A. Jensen, J.I. Mullins, R.S. Hogg, J.S.G. Montaner and P.R. Harrigan. 2003. Clinical and immunological impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy. AIDS 18: F1-F9.
Shriner, D., D.C. Nickle, M.A. Jensen, and J.I. Mullins. 2003. The potential impact of recombination on sitewise approaches for detecting positive natural selection. Genet. Res. 81: 115-121.
Nickle, D.C., M.A. Jensen, D. Shriner, S.J. Brodie, L.M. Frenkel, J.E. Mittler, and J.I. Mullins. 2003. Evolutionary indicators of HIV-1 reservoirs and compartments. J. Virol. 77: 5540-5546.
Dybul, M., M. Daucher, M.A. Jensen, C.W. Hallahan, T.-W. Chun, M. Belson, B. Hidalgo, D.C. Nickle, C. Yoder, J.A. Metcalf, R.T. Davey, L. Ehler, D. Kress-Rock, E. Nies-Kraske, S. Liu, J.I. Mullins and A.S. Fauci. 2003. Genetic characterization of rebounding plasma HIV-1 during multiple interruptions of highly active antiretroviral therapy. J. Virol. 77: 3229-3237.