Faculty

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Harry A. Dailey, Ph.D.
Professor of Microbiology and Biochemistry & Molecular Biology,
Director of the Biomedical and Health Sciences Institute
Ph.D. (1976) UCLA

Address: Departments of Microbiology and
Biochemistry & Molecular Biology
A222 Life Sciences Building
Athens, GA 30602-7229
Phone: (706) 542-2690
E-mail: hdailey@uga.edu
COS CV: http://myprofile.cos.com/daileyh30
PubMed: dailey h

Research Interests:
Our laboratory has two distinct ongoing projects. One is the production of purified human proteins for the NIH-supported Southeastern Collaboratory for Structural Genomics (SECSG). For this work our goal is to express and purify all human cDNAs using a high throughput system designed to produce 200-500 proteins per year. Protein targets include cancer marker proteins.

The second project involves study of the enzymes of tetrapyrrole biosynthesis. There are two major long-range goals for our laboratory's research in the field of tetrapyrrole biosynthesis. The first is to characterize at the biochemical and molecular level the terminal enzymes of the heme biosynthetic pathway and the second is to examine regulatory mechanisms of heme biosynthesis that exist in erythroid and non-erythroid cell types. An integral part of both of these goals is to understand at both a biochemical and cellular level the specific nature of the human genetic diseases variegate porphyria (VP), and erythropoietic protoporphyria (EPP). We have recently established both cell lines and a murine model for the "South African" variegate porphyria in order to gain an understanding of the biochemical basis for variable penetrance, and why symptomatic patients exhibit significantly different intensities of symptoms.